Engineering trypsin‐fold serine proteases for inhibitor resistance
نویسندگان
چکیده
منابع مشابه
Correction : Serine Proteases in Histone Deacetylase Inhibitor – Induced Apoptosis – Letter
tivatin In an elicite obser induc trigge butyr toxic dition 10 da seeme prote rather If th TSA o idea We fo itory tion u inhibi with tone deacetylase inhibitors (HDACi) are a new of targeted antitumor agents (1). They exert their y against cancer cells by stimulating differentiation, ibiting proliferation, and by inducing apoptosis. ugh the latter has been extensively studied, our rstanding of ...
متن کاملSerine proteases in histone deacetylase inhibitor-induced apoptosis.
tivatin In an elicite obser induc trigge butyr toxic dition 10 da seeme prote rather If th TSA o idea We fo itory tion u inhibi with tone deacetylase inhibitors (HDACi) are a new of targeted antitumor agents (1). They exert their y against cancer cells by stimulating differentiation, ibiting proliferation, and by inducing apoptosis. ugh the latter has been extensively studied, our rstanding of ...
متن کاملSerine Proteases of Parasitic Helminths
Serine proteases form one of the most important families of enzymes and perform significant functions in a broad range of biological processes, such as intra- and extracellular protein metabolism, digestion, blood coagulation, regulation of development, and fertilization. A number of serine proteases have been identified in parasitic helminths that have putative roles in parasite development an...
متن کاملReaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor.
The mechanism-based inactivations of a number of serine proteases, including human leukocyte (HL) elastase, cathepsin G, rat mast cell proteases I and II, several human and bovine blood coagulation proteases, and human factor D by substituted isocoumarins and phthalides which contain masked acyl chloride or anhydride moieties, are reported. 3,4-Dichloroisocoumarin, the most potent inhibitor inv...
متن کاملInhibition of serine proteases by arylboronic acids.
Arylboronic acids were found to be strong competitive inhibitors of subtilisin and chymotrypsin. The binding constants are strongly pH dependent and give a Hammett-type plot with a slope of -0.885. The pH dependence, the Hammett plot, and nmr model-system studies indicate that inhibition is due to electron-pair donation by the active site histidine to the bound inhibitor.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.561.12